- Notice: Undefined index: title_shortcut in Drupal\esante_sommaire\EsanteSommaireUtils::decoupe_node() (line 84 of modules/custom/sommaire/src/EsanteSommaireUtils.php).
Drupal\esante_sommaire\EsanteSommaireUtils::decoupe_node('$$Qu'est ce que métabolisme osseux ?$$L'os est un organe vivant en perpétuel remaniement ; il se développe pendant la croissance et tout au long de la vie. Certaines de ces cellules participent à sa construction (ostéoblastes) et d'autres cellules, à sa destruction (ostéoclastes). Le remaniement perpétuel du tissu osseux constitue le métabolisme osseux. L'os se compose principalement d'une trame de protéines, de calcium et de phosphore. Les mouvements de calcium et de phosphore dans l'organisme (dosés dans le sang et/ou dans les urines) sont donc un reflet indirect du métabolisme osseux.$$Pourquoi un bilan biologique du métabolisme osseux ?$$Le métabolisme osseux est un bilan biologique qui cherche d'une part à apprécier, à l'aide de différents dosages dans le sang et/ou dans les urines, les activités de remaniement ou de remodelage du tissu osseux.D'autre part, il contribue à mettre en évidence des anomalies quantitatives (excès ou insuffisance du remodelage osseux) et des anomalies qualitatives (défaut de minéralisation de l'os).$$Quels sont les examens demandés pour un bilan biologique du métabolisme osseux ?$$L'exploration du bilan du métabolisme osseux repose sur trois groupes d'examens biologiques.<ul><li> <strong> L'exploration du métabolisme phosphocalcique :</strong> elle évalue les mouvements de phosphore (ou phosphate) et de calcium dans l'organisme en dosant les taux plasmatiques et urinaires de ces différents ions : ##15533/bilan phosphocalcique/##</li> <li> <strong>Le dosage des marqueurs de l'activité de remodelage de l'os :</strong> on différencie les marqueurs de la résorption osseuse (destruction de l'os) et les marqueurs plus spécifiques de la formation de l'os. </li></ul><strong>Les marqueurs de la formation osseuse : </strong> <ul><li> Phosphatases alcalines osseuses : ce sont des enzymes produites par le tissu osseux.</li> <li> ##13259/Ostéocalcine/## ou ##66991/thyrocalcitonine/## : c'est une protéine constitutive des os, bon marqueur du renouvellement osseux. </li> </ul><strong>Les marqueurs de la résorption osseuse : </strong> <ul><li> ##13185/Télopeptides [télopeptide C terminal du collagène de type I (Cross-laps ou CTx)/## ; ##67044/Télopeptide N terminal du collagène de type I (NTx)]/##.</li> <li> Cross-links [pyridinoline (Pyr) et désoxypyridinoline (DpD)] : ils sont dosés conjointement (Cross-links) ou séparément (Pyr ou DpD).</li> <li> ##14660/Hydroxyproline/## (OH proline) urinaire : ce dosage est aujourd'hui relativement obsolète car ce marqueur n'est pas spécifique de l'os.</li> </ul><strong>Le dosage des hormones ayant une influence sur le métabolisme osseux et/ou sur le bilan phosphocalcique.</strong> Ces dosages ont surtout pour objectif d'identifier, tantôt l'origine de l'anomalie du métabolisme osseux, tantôt d'apprécier le retentissement de l'anomalie sur la physiologie de l'organisme. <ul><li> ##14738/Dosage de la parathormone (PTH)/## </li> <li> ##66934/Vitamine D 3/##</li> <li> Calcitonine (thyrocalcitonine)</li> </ul>', 1, '15416') (Line: 51)
esante_sommaire_node_view(Array, Object, Object, 'full')
call_user_func_array('esante_sommaire_node_view', Array) (Line: 403)
Drupal\Core\Extension\ModuleHandler->invokeAll('node_view', Array) (Line: 299)
Drupal\Core\Entity\EntityViewBuilder->buildMultiple(Array) (Line: 250)
Drupal\Core\Entity\EntityViewBuilder->build(Array)
call_user_func_array(Array, Array) (Line: 100)
Drupal\Core\Render\Renderer->doTrustedCallback(Array, Array, 'Render #pre_render callbacks must be methods of a class that implements \Drupal\Core\Security\TrustedCallbackInterface or be an anonymous function. The callback was %s. Support for this callback implementation is deprecated in 8.8.0 and will be removed in Drupal 9.0.0. See https://www.drupal.org/node/2966725', 'silenced_deprecation', 'Drupal\Core\Render\Element\RenderCallbackInterface') (Line: 781)
Drupal\Core\Render\Renderer->doCallback('#pre_render', Array, Array) (Line: 372)
Drupal\Core\Render\Renderer->doRender(Array, ) (Line: 200)
Drupal\Core\Render\Renderer->render(Array, ) (Line: 226)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 573)
Drupal\Core\Render\Renderer->executeInRenderContext(Object, Object) (Line: 227)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare(Array, Object, Object) (Line: 117)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse(Array, Object, Object) (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray(Object, 'kernel.view', Object)
call_user_func(Array, Object, 'kernel.view', Object) (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch('kernel.view', Object) (Line: 156)
Symfony\Component\HttpKernel\HttpKernel->handleRaw(Object, 1) (Line: 68)
Symfony\Component\HttpKernel\HttpKernel->handle(Object, 1, 1) (Line: 57)
Drupal\Core\StackMiddleware\Session->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\KernelPreHandle->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle(Object, 1, 1) (Line: 52)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle(Object, 1, 1) (Line: 23)
Stack\StackedHttpKernel->handle(Object, 1, 1) (Line: 694)
Drupal\Core\DrupalKernel->handle(Object) (Line: 19)
- Notice: Undefined offset: 0 in esante_entity_view() (line 89 of modules/custom/esante/esante.module).
esante_entity_view(Array, Object, Object, 'full')
call_user_func_array('esante_entity_view', Array) (Line: 403)
Drupal\Core\Extension\ModuleHandler->invokeAll('entity_view', Array) (Line: 300)
Drupal\Core\Entity\EntityViewBuilder->buildMultiple(Array) (Line: 250)
Drupal\Core\Entity\EntityViewBuilder->build(Array)
call_user_func_array(Array, Array) (Line: 100)
Drupal\Core\Render\Renderer->doTrustedCallback(Array, Array, 'Render #pre_render callbacks must be methods of a class that implements \Drupal\Core\Security\TrustedCallbackInterface or be an anonymous function. The callback was %s. Support for this callback implementation is deprecated in 8.8.0 and will be removed in Drupal 9.0.0. See https://www.drupal.org/node/2966725', 'silenced_deprecation', 'Drupal\Core\Render\Element\RenderCallbackInterface') (Line: 781)
Drupal\Core\Render\Renderer->doCallback('#pre_render', Array, Array) (Line: 372)
Drupal\Core\Render\Renderer->doRender(Array, ) (Line: 200)
Drupal\Core\Render\Renderer->render(Array, ) (Line: 226)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 573)
Drupal\Core\Render\Renderer->executeInRenderContext(Object, Object) (Line: 227)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare(Array, Object, Object) (Line: 117)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse(Array, Object, Object) (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray(Object, 'kernel.view', Object)
call_user_func(Array, Object, 'kernel.view', Object) (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch('kernel.view', Object) (Line: 156)
Symfony\Component\HttpKernel\HttpKernel->handleRaw(Object, 1) (Line: 68)
Symfony\Component\HttpKernel\HttpKernel->handle(Object, 1, 1) (Line: 57)
Drupal\Core\StackMiddleware\Session->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\KernelPreHandle->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle(Object, 1, 1) (Line: 52)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle(Object, 1, 1) (Line: 23)
Stack\StackedHttpKernel->handle(Object, 1, 1) (Line: 694)
Drupal\Core\DrupalKernel->handle(Object) (Line: 19)
- Notice: Only variables should be passed by reference in Drupal\esante_lists\EsanteListsUtils::getArboImage() (line 41 of modules/custom/lists/src/EsanteListsUtils.php).
Drupal\esante_lists\EsanteListsUtils::getArboImage(Object, , 'image_490') (Line: 36)
Drupal\esante_lists\EsanteListsUtils::node_field_img_fallback(Object) (Line: 261)
esante_lists_node_view_alter(Array, Object, Object) (Line: 539)
Drupal\Core\Extension\ModuleHandler->alter('node_view', Array, Object, Object) (Line: 316)
Drupal\Core\Entity\EntityViewBuilder->buildMultiple(Array) (Line: 250)
Drupal\Core\Entity\EntityViewBuilder->build(Array)
call_user_func_array(Array, Array) (Line: 100)
Drupal\Core\Render\Renderer->doTrustedCallback(Array, Array, 'Render #pre_render callbacks must be methods of a class that implements \Drupal\Core\Security\TrustedCallbackInterface or be an anonymous function. The callback was %s. Support for this callback implementation is deprecated in 8.8.0 and will be removed in Drupal 9.0.0. See https://www.drupal.org/node/2966725', 'silenced_deprecation', 'Drupal\Core\Render\Element\RenderCallbackInterface') (Line: 781)
Drupal\Core\Render\Renderer->doCallback('#pre_render', Array, Array) (Line: 372)
Drupal\Core\Render\Renderer->doRender(Array, ) (Line: 200)
Drupal\Core\Render\Renderer->render(Array, ) (Line: 226)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 573)
Drupal\Core\Render\Renderer->executeInRenderContext(Object, Object) (Line: 227)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare(Array, Object, Object) (Line: 117)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse(Array, Object, Object) (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray(Object, 'kernel.view', Object)
call_user_func(Array, Object, 'kernel.view', Object) (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch('kernel.view', Object) (Line: 156)
Symfony\Component\HttpKernel\HttpKernel->handleRaw(Object, 1) (Line: 68)
Symfony\Component\HttpKernel\HttpKernel->handle(Object, 1, 1) (Line: 57)
Drupal\Core\StackMiddleware\Session->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\KernelPreHandle->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle(Object, 1, 1) (Line: 52)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle(Object, 1, 1) (Line: 23)
Stack\StackedHttpKernel->handle(Object, 1, 1) (Line: 694)
Drupal\Core\DrupalKernel->handle(Object) (Line: 19)
- Notice: Undefined offset: 0 in esante_theme_preprocess_node() (line 353 of themes/esante_theme/esante_theme.theme).
esante_theme_preprocess_node(Array, 'node', Array) (Line: 287)
Drupal\Core\Theme\ThemeManager->render('node', Array) (Line: 431)
Drupal\Core\Render\Renderer->doRender(Array, ) (Line: 200)
Drupal\Core\Render\Renderer->render(Array, ) (Line: 226)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 573)
Drupal\Core\Render\Renderer->executeInRenderContext(Object, Object) (Line: 227)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare(Array, Object, Object) (Line: 117)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse(Array, Object, Object) (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray(Object, 'kernel.view', Object)
call_user_func(Array, Object, 'kernel.view', Object) (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch('kernel.view', Object) (Line: 156)
Symfony\Component\HttpKernel\HttpKernel->handleRaw(Object, 1) (Line: 68)
Symfony\Component\HttpKernel\HttpKernel->handle(Object, 1, 1) (Line: 57)
Drupal\Core\StackMiddleware\Session->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\KernelPreHandle->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle(Object, 1, 1) (Line: 52)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle(Object, 1, 1) (Line: 23)
Stack\StackedHttpKernel->handle(Object, 1, 1) (Line: 694)
Drupal\Core\DrupalKernel->handle(Object) (Line: 19)
- Notice: Undefined variable: tid in esante_theme_preprocess_node() (line 376 of themes/esante_theme/esante_theme.theme).
esante_theme_preprocess_node(Array, 'node', Array) (Line: 287)
Drupal\Core\Theme\ThemeManager->render('node', Array) (Line: 431)
Drupal\Core\Render\Renderer->doRender(Array, ) (Line: 200)
Drupal\Core\Render\Renderer->render(Array, ) (Line: 226)
Drupal\Core\Render\MainContent\HtmlRenderer->Drupal\Core\Render\MainContent\{closure}() (Line: 573)
Drupal\Core\Render\Renderer->executeInRenderContext(Object, Object) (Line: 227)
Drupal\Core\Render\MainContent\HtmlRenderer->prepare(Array, Object, Object) (Line: 117)
Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse(Array, Object, Object) (Line: 90)
Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray(Object, 'kernel.view', Object)
call_user_func(Array, Object, 'kernel.view', Object) (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch('kernel.view', Object) (Line: 156)
Symfony\Component\HttpKernel\HttpKernel->handleRaw(Object, 1) (Line: 68)
Symfony\Component\HttpKernel\HttpKernel->handle(Object, 1, 1) (Line: 57)
Drupal\Core\StackMiddleware\Session->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\KernelPreHandle->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle(Object, 1, 1) (Line: 52)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle(Object, 1, 1) (Line: 23)
Stack\StackedHttpKernel->handle(Object, 1, 1) (Line: 694)
Drupal\Core\DrupalKernel->handle(Object) (Line: 19)
- Warning: array_flip(): Can only flip STRING and INTEGER values! in Drupal\Core\Entity\EntityStorageBase->loadMultiple() (line 266 of core/lib/Drupal/Core/Entity/EntityStorageBase.php).
Drupal\Core\Entity\EntityStorageBase->loadMultiple(Array) (Line: 250)
Drupal\Core\Entity\EntityStorageBase->load() (Line: 532)
Drupal\Core\Entity\EntityBase::load() (Line: 67)
Drupal\esante_guides\Plugin\Block\EsanteGuidesBlockRubrique->build() (Line: 171)
Drupal\block\BlockViewBuilder::preRender(Array)
call_user_func_array(Array, Array) (Line: 100)
Drupal\Core\Render\Renderer->doTrustedCallback(Array, Array, 'Render #pre_render callbacks must be methods of a class that implements \Drupal\Core\Security\TrustedCallbackInterface or be an anonymous function. The callback was %s. Support for this callback implementation is deprecated in 8.8.0 and will be removed in Drupal 9.0.0. See https://www.drupal.org/node/2966725', 'silenced_deprecation', 'Drupal\Core\Render\Element\RenderCallbackInterface') (Line: 781)
Drupal\Core\Render\Renderer->doCallback('#pre_render', Array, Array) (Line: 372)
Drupal\Core\Render\Renderer->doRender(Array, 1) (Line: 200)
Drupal\Core\Render\Renderer->render(Array, 1) (Line: 156)
Drupal\Core\Render\Renderer->Drupal\Core\Render\{closure}() (Line: 573)
Drupal\Core\Render\Renderer->executeInRenderContext(Object, Object) (Line: 157)
Drupal\Core\Render\Renderer->renderPlain(Array) (Line: 171)
Drupal\Core\Render\Renderer->renderPlaceholder('', Array) (Line: 658)
Drupal\Core\Render\Renderer->replacePlaceholders(Array) (Line: 543)
Drupal\Core\Render\Renderer->doRender(Array, 1) (Line: 200)
Drupal\Core\Render\Renderer->render(Array, 1) (Line: 144)
Drupal\Core\Render\Renderer->Drupal\Core\Render\{closure}() (Line: 573)
Drupal\Core\Render\Renderer->executeInRenderContext(Object, Object) (Line: 145)
Drupal\Core\Render\Renderer->renderRoot(Array) (Line: 282)
Drupal\Core\Render\HtmlResponseAttachmentsProcessor->renderPlaceholders(Object) (Line: 131)
Drupal\Core\Render\HtmlResponseAttachmentsProcessor->processAttachments(Object) (Line: 45)
Drupal\Core\EventSubscriber\HtmlResponseSubscriber->onRespond(Object, 'kernel.response', Object)
call_user_func(Array, Object, 'kernel.response', Object) (Line: 111)
Drupal\Component\EventDispatcher\ContainerAwareEventDispatcher->dispatch('kernel.response', Object) (Line: 191)
Symfony\Component\HttpKernel\HttpKernel->filterResponse(Object, Object, 1) (Line: 173)
Symfony\Component\HttpKernel\HttpKernel->handleRaw(Object, 1) (Line: 68)
Symfony\Component\HttpKernel\HttpKernel->handle(Object, 1, 1) (Line: 57)
Drupal\Core\StackMiddleware\Session->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\KernelPreHandle->handle(Object, 1, 1) (Line: 47)
Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle(Object, 1, 1) (Line: 52)
Drupal\Core\StackMiddleware\NegotiationMiddleware->handle(Object, 1, 1) (Line: 23)
Stack\StackedHttpKernel->handle(Object, 1, 1) (Line: 694)
Drupal\Core\DrupalKernel->handle(Object) (Line: 19)